SR 142948

MedChem Express

SR 142948 [184162-64-9]

5

184162-64-9

Research Use Only

99.16

C39H51N5O6

685.85

SR 142948 is an orally active and selective non-peptide neurotensin receptor ( NT ) antagonist with IC 50 s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders [1] [2] .

O=C(C1=NN(C2=C(C=C(C(N(C)CCCN(C)C)=O)C=C2)C(C)C)C(C3=C(C=CC=C3OC)OC)=C1)NC4([C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)C(O)=O

-20°C,2°C to 8°C

12352200