SR-33805 [121346-32-5]

TargetMol Chemicals

SR-33805 [121346-32-5]

72

121346-32-5

Research Use Only

SR-33805

C32H40N2O5S

564.74

SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.

3 years

S(=O)(=O)(C1=C(C(C)C)C=2C(N1C)=CC=CC2)C3=CC=C(OCCCN(CCC4=CC(OC)=C(OC)C=C4)C)C=C3

-20°C

12352200