SR-4835

MedChem Express

SR-4835 [2387704-62-1]

10

2387704-62-1

Research Use Only

99.82

C21H20Cl2N10O

499.36

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC 50 =99 nM, K d =98 nM; CDK13: K d =4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death [1] .

CN1N=CC(N2C3=NC(N4CCOCC4)=NC(NCC5=NC6=C(N5)C=C(Cl)C(Cl)=C6)=C3N=C2)=C1

-20°C,2°C to 8°C

12352200