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SRI-29132

SRI-29132

T34706
TargetMol Chemicals
CAS Number1482305-44-1
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Product group Chemicals
Molecular Weight387.52
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SRI-29132
  • Delivery Days Customer
    65
  • CAS Number
    1482305-44-1
  • Category Supplier
    Chemical
  • Chemical Name
    SRI-29132
  • Molecular Formula
    C18H21N5OS2
  • Molecular Weight
    387.52
  • Scientific Description
    SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.
  • Shelf life instruction
    3 years
  • SMILES
    S(C(C(=O)N1CCCCC1)CC)C2=NN3C(=NN=C3C=C2)C4=CC=CS4
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. PubMed PMID: 25228699; PubMed Central PMCID: PMC4239640.
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