SRI-42127 [2727872-68-4]

MedChem Express

SRI-42127 [2727872-68-4]

10

2727872-68-4

Research Use Only

99.80

C19H20N6O

348.40

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1].

CN(C1CCOCC1)C2=NN3C(C=C2)=NC=C3C4=CC5=C(C=C4)C=NN5

-20°C,2°C to 8°C

12131703