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(S,R,S)-AHPC

HY-125845
MedChem Express
CAS Number1448297-52-6
DownloadMSDS
Product group Chemicals
Estimated Purity99.13
Molecular Weight430.56
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (S,R,S)-AHPC [1448297-52-6]
  • Delivery Days Customer
    10
  • CAS Number
    1448297-52-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.13
  • Molecular Formula
    C22H30N4O3S
  • Molecular Weight
    430.56
  • Scientific Description
    (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC 50 of 1.11 microM in Ba/F3 cells [1] .
  • SMILES
    O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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