(S,R,S)-AHPC

MedChem Express

(S,R,S)-AHPC [1448297-52-6]

10

1448297-52-6

Research Use Only

99.13

C22H30N4O3S

430.56

(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC 50 of 1.11 microM in Ba/F3 cells [1] .

O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2

-20°C,2°C to 8°C

12352200