(S,R,S)-MI-1061
HY-125858B
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product Name(S,R,S)-MI-1061
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC30H26Cl2FN3O4
- Molecular Weight582.45
- Scientific Description(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].
- SMILESO=C1[C@@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N[C@@H]([C@H]2C5=C(C(Cl)=CC=C5)F)C(NC6=CC=C(C=C6)C(O)=O)=O
- UNSPSC41115800