SRS16-86

Biorbyt

SRS16-86 [1793052-96-6]

10

1793052-96-6

Research Use Only

C26H32N4O2

432.5579

SRS16-86 is an inhibitor of ferroptosis. It inhibits ferroptosis induced by erastin in HT-1080 and NIH3T3 cells. SRS16-86 prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 increases the levels of glutathione peroxidase 4 (GPX4), system xc- cystine/glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1beta, TNF-alpha, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters. It also increases tissue sparing and improves locomotor recovery in the same model.

O(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C1C([H])=C([H])C(=C(C=1[H])/N=C(/[H])\C1=C([H])N=C([H])N=C1[H])N([H])C12C([H])([H])C3([H])C([H])([H])C([H])(C([H])([H])C([H])(C3([H])[H])C1([H])[H])C2([H])[H])=O

12352200