SS47 [2636072-62-1]

TargetMol Chemicals

SS47 [2636072-62-1]

16

Chemical

Research Use Only

SS47

C49H56N6O12S

953.07

SS47, a PROTAC-based HPK1 degrader, induces proteasome-mediated HPK1 degradation and significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell research. HPK1, an immunosuppressive regulatory kinase, is a promising target for cancer immunotherapies [1].

3 years

O=C1C=2C=CC=C(OCCOCCOCCOCCOCCC(=O)N3CCC(C4=NC=C(S4)C=5C=NC(N)=C(OCC=6C=CC=C(C#CC(O)(C)C)C6)C5)CC3)C2C(=O)N1C7C(=O)NC(=O)CC7

-20°C

12352200