SSO111 (sodium)

MedChem Express

SSO111 (sodium)

5

Research Use Only

SSO111 sodium, a 20mer fully modified antisense oligonucleotide, targets the oncogene HER2. SSO111 sodium induces exon 15 skipping during splicing, leading to the generation of a novel mRNA transcript that excludes exon 15. SSO111 sodium downregulated HER2 mRNA, which resulted in the inhibition of proliferation and induction of apoptosis in HER2-overexpressing tumor cells.

[SSO111 (sodium)]

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