SST0116CL1

MedChem Express

SST0116CL1

9

Research Use Only

C22H31ClN4O6

482.96

SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 microM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 microM). SST0116CL1 has antiproliferative activity and inhibits tumor growth[1].

O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O.Cl

12352200