SST0116CL1

Biorbyt

SST0116CL1

10

Research Use Only

98.00%

C22H31ClN4O6

482.96

SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 microM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 microM) and exhibits antiproliferative activity, inhibiting tumor growth.

Cl.O=C(NCC)C1=NOC(C=2C=C(C(O)=CC2O)C(C)C)=C1NC(=O)CCN3CCOCC3

-20°C

12352200