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Western Blot analysis of 293 cells using Stat1 Polyclonal Antibody at dilution of 1:2000.
Western Blot analysis of 293 cells using Stat1 Polyclonal Antibody at dilution of 1:2000.
Western Blot analysis of 293 cells using Stat1 Polyclonal Antibody at dilution of 1:2000.

Stat1 Polyclonal Antibody

Research Use Only
E-AB-32977
Elabscience
Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    Elabscience
  • Product Name
    Stat1 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Applications Supplier
    WB,IHC,ELISA
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Scientific Description
    Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
  • UNSPSC
    12352203