Stearoyl Serotonin [67964-87-8]

MedChem Express

Stearoyl Serotonin [67964-87-8]

5

Research Use Only

C28H46N2O2

442.68

Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation (IC50=0.76 microM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 microM).

O=C(CCCCCCCCCCCCCCCCC)NCCC1=CNC2=CC=C(C=C12)O

12352200