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Stemregenin 1 (GMP) [1227633-49-9]

HY-15001G
MedChem Express
CAS Number1227633-49-9
Product group Chemicals
Estimated Purity99.70
Molecular Weight429.54
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Stemregenin 1 (GMP) [1227633-49-9]
  • Delivery Days Customer
    5
  • CAS Number
    1227633-49-9
  • Certification
    Research Use Only
  • Estimated Purity
    99.70
  • Molecular Formula
    C24H23N5OS
  • Molecular Weight
    429.54
  • Scientific Description
    Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC50 of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-kappaB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the treatment of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases[1][2][3][4].
  • SMILES
    CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703

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