Stemregenin 1 (GMP) [1227633-49-9]
HY-15001G
CAS Number1227633-49-9
Product group Chemicals
Estimated Purity99.70
Molecular Weight429.54
Overview
- SupplierMedChem Express
- Product NameStemregenin 1 (GMP) [1227633-49-9]
- Delivery Days Customer5
- CAS Number1227633-49-9
- CertificationResearch Use Only
- Estimated Purity99.70
- Molecular FormulaC24H23N5OS
- Molecular Weight429.54
- Scientific DescriptionStemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC50 of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-kappaB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the treatment of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases[1][2][3][4].
- SMILESCC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1
- Storage Instruction2°C to 8°C
- UNSPSC12131703