StemRegenin1 (SR1) --- HSC Expansion Molecule

Bioss

StemRegenin1 (SR1) --- HSC Expansion Molecule [1227633-49-9]

16

Research Use Only

98.0

StemRegenin1 (SR1) is a selective, cell-permeable antagonist of aryl hydrocarbon receptor. It can promote robust expansion and self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs, EC50 ~120 nM). SR1 expanded CD34+ cells from bone marrow of humans, monkeys and dogs, but not mice. Culture of HSCs with 1 microM SR1 for 21 days led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Currently Novartis is conducting clinical trials, LFU835-expanded Umbilical Cord Blood Hematopoietic Stem Cells in Patients With Hematological Malignancies, related to this research.

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51202000