SU-11752 [688036-19-3]

MedChem Express

SU-11752 [688036-19-3]

5

688036-19-3

Research Use Only

C26H27N3O5S

493.57

SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 microM. SU-11752 inhibits PI3K p110gamma kinase with IC50 of 1.1 microM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy[1].

O=C(CCC1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(NC4=CC=CC=C4)=O)=O)=C1CC)CC)O

12352200