Sunitinib

MedChem Express

Sunitinib [557795-19-4]

10

557795-19-4

Research Use Only

99.69

C22H27FN4O2

398.47

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC 50 s of 80 nM and 2 nM for VEGFR2 and PDGFRbeta , respectively [1] . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1alpha by inhibiting autophosphorylation and consequent RNase activation [2] .

O=C(NCCN(CC)CC)C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)F)=O)=C1C)C

2°C to 8°C

12352200