Superoxide Dismutase [9054-89-1]

Athens Research

Superoxide Dismutase [9054-89-1]

9

Cell Culture Media, In Vitro Diagnostics, Oxidative Sstress, amyotrophic lateral sclerosis , Pakinson's, Alzheimer's, Cardiovascular Disease, Inflammation, Cancer

9054-89-1

Research Use Only

≥95% by SDS-PAGE

Superoxide dismutase [Cu-Zn]

Superoxide dismutase (SOD) is a critical antioxidant enzyme present in nearly all living cells exposed to oxygen. It catalyzes the rapid conversion of superoxide radicals-harmful byproducts of cellular metabolism-into hydrogen peroxide and molecular oxygen, thereby protecting cells from oxidative damage. SOD achieves this through highly efficient redox cycling at its active site, which contains essential metal cofactors such as copper, zinc, manganese, or iron, depending on the SOD isoform. These metal ions facilitate electron transfer, enabling SOD to neutralize superoxide radicals at rates limited only by molecular diffusion. Functionally, SOD plays a vital role in cellular defense against oxidative stress, maintaining metabolic and mitochondrial integrity. Mutations in the SOD1 gene are linked to familial amyotrophic lateral sclerosis (ALS), while altered SOD activity is implicated in diseases such as Parkinson’s, Alzheimer’s, Down syndrome, cardiovascular disease, and various inflammatory and neurodegenerative disorders. Clinically, SOD and its recombinant forms are being explored for therapeutic applications in conditions characterized by oxidative stress, including cardiovascular disease, traumatic brain injury, cancer, dermatological disorders, and inflammatory diseases. SOD activity is also used as a biomarker for oxidative stress and tissue health in both research and clinical diagnostics.

more then 1 year

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

≤ -20°C

12352202