Suramin . hexasodium salt [129-46-4]

AdipoGen Life Sciences

Suramin . hexasodium salt

10

129-46-4

Research Use Only

>98%

C51H34N6O23S6 . 6Na

1291.2 . 137.9

Chemical. CAS: 129-46-4. Formula: C51H34N6O23S6 . 6Na. MW: 1291.2 . 137.9. Synthetic. Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (sirtuin 1) and SIRT5 (sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Cullin-RING E3 ubiquitin ligase inhibitor. - Potent ATPase inhibitor [1]. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity [2, 3]. Anticancer compound [4, 5, 15]. Protein kinase C (PKC) inhibitor [4]. Potent inhibitor of melanoma heparanase and tumor cell metastasis [6]. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF) [7, 16]. TGF-beta1 inhibitor [8]. Topoisomerase I and II inhibitor [9]. Interleukin-1 (IL-1) inhibitor [10]. Interleukin-4 (IL-4) inhibitor [11]. G protein inhibitor [12]. P2X and P2Y purinergic receptor antagonist [13]. Antiangiogenic. Potent VEGF inhibitor [14, 15]. Telomerase inhibitor [17]. Shows adjuvant properties [18]. Regulates ryanodine receptor [19]. Direct adenylyl cyclase inhibitor [20]. Protein synthesis inhibitor [21]. SIRT1 (sirtuin 1) and SIRT5 (sirtuin 5) inhibitor [22, 23]. Immunosuppressive [24]. Antifibrotic agent [25]. Antiparasitic. Antiprotozoal. Athelmintic [26]. Cullin-RING E3 ubiquitin ligase inhibitor [27]. Inhibitor of the STING pathway via the inhibition of cGAMP synthase (cGAS) enzymatic activity. Inhibits SARS-CoV-2 infection in cell culture by blocking early steps (binding/fusion) of the replication cycle. Potentially binds and inhibits nsp12 of SARS-CoV-2, binding to motifs harbouring the RNA-dependent RNA polymerases (RdRps) activity.

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=CC=C1)C(=O)NC1=CC=C(C2=C1C(=CC(=C2)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

2°C to 8°C

12352200