Suramin (sodium salt)

MedChem Express

Suramin (sodium salt) [129-46-4]

10

129-46-4

Research Use Only

99.48

C51H34N6Na6O23S6

1429.17

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor [1] . Suramin sodium salt is a potent inhibitor of sirtuins : SirT1 ( IC 50 =297 nM), SirT2 ( IC 50 =1.15 microM), and SirT5 ( IC 50 =22 microM) [2] . Suramin sodium salt is a competitive inhibitor of reverse transcriptase ( DNA topoisomerase II : IC 50 =5 microM) [3] [4] . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor [5] . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic , anti-neoplastic and anti-angiogenic agent [6] [7] [8] .

O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6C)=O)=CC=C5

2°C to 8°C

12352200