Survivin antibody
GTX100052
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetBIRC5
Overview
- SupplierGeneTex
- Product NameSurvivin antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID332
- Target nameBIRC5
- Target descriptionbaculoviral IAP repeat containing 5
- Target synonymsAPI4; apoptosis inhibitor 4; apoptosis inhibitor survivin; baculoviral IAP repeat-containing protein 5; EPR-1; survivin variant 3 alpha
- HostRabbit
- IsotypeIgG
- Protein IDO15392
- Protein NameBaculoviral IAP repeat-containing protein 5
- Scientific DescriptionSurvivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this genes expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- RUNX1-Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors.Read more
- A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.Read more
- Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3beta-beta-Catenin and XIAP-Survivin Pathways. Chang YX et al., 2020 Dec 21, Cancers (Basel)Read more
- Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/beta-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis. Fan HC et al., 2020 Nov 22, Int J Mol SciRead more
- Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells. Lin TY et al., 2021 Jan, PhytomedicineRead more
- Expression of FOXM1 and Aurora-A predicts prognosis and sorafenib efficacy in patients with hepatocellular carcinoma. Su WL et al., 2020, Cancer BiomarkRead more
- The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-beta Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1. Lee HJ et al., 2019, Front ImmunolRead more
- Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Liu YH et al., 2018 Jul 15, PhytomedicineRead more
- Inflammatory interferon activates HIF-1alpha-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway. Yeh YH et al., 2018 Mar 27, J Exp Clin Cancer ResRead more
- MiR-182 affects renal cancer cell proliferation, apoptosis, and invasion by regulating PI3K/AKT/mTOR signaling pathway. Fu JH et al., 2018 Jan, Eur Rev Med Pharmacol SciRead more