Sweroside [14215-86-2]

MedChem Express

Sweroside [14215-86-2]

9

14215-86-2

Research Use Only

99.76

C16H22O9

358.34

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-kappaB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-kappaB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields[1][2][3][4].

C=C[C@@H]1[C@@](CCOC2=O)([H])C2=CO[C@H]1O[C@]([C@@H]([C@@H](O)[C@@H]3O)O)([H])O[C@@H]3CO

2°C to 8°C

12131703