SYN1143

MedChem Express

SYN1143 [913376-84-8]

10

913376-84-8

Research Use Only

99.36

C31H29FN4O5

556.58

SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON , with IC 50 s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck , Tie2 , Src , and BTK with IC 50 s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated [1] .

O=C(C1=C(C)N(CC(C)(O)C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(OC4=CC=NC5=CC(OC)=CC=C45)C(F)=C3

-20°C,2°C to 8°C

12352200