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IHC-P analysis of mouse skeletal muscle tissue using GTX85139 SYNPO2 antibody. Working concentration : 5 microg/ml
IHC-P analysis of mouse skeletal muscle tissue using GTX85139 SYNPO2 antibody. Working concentration : 5 microg/ml
IHC-P analysis of mouse skeletal muscle tissue using GTX85139 SYNPO2 antibody. Working concentration : 5 microg/ml

SYNPO2 antibody

GTX85139
GeneTex
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
TargetSYNPO2
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Overview

  • Supplier
    GeneTex
  • Product Name
    SYNPO2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID171024
  • Target name
    SYNPO2
  • Target description
    synaptopodin 2
  • Target synonyms
    genethonin-2; myopodin; synaptopodin-2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UMS6
  • Protein Name
    Synaptopodin-2
  • Scientific Description
    SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Role of chaperone-assisted selective autophagy (CASA) in mechanical stress protection of periodontal ligament cells. Salim C et al., 2022 Jan, J Orofac Orthop
    Read more

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Figure 1. Western blot analysis of SYNPO2 using anti-SYNPO2 antibody (A07616-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human SH-SY5Y whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SYNPO2 antigen affinity purified polyclonal antibody (Catalog # A07616-1) at 0.25 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for SYNPO2 at approximately 160 kDa. The expected band size for SYNPO2 is at 118 kDa.
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