Syntrophin alpha 1 antibody, N-term

GeneTex

Syntrophin alpha 1 antibody, N-term

7

WB: 1-3microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

SNTA1

syntrophin alpha 1

59 kDa dystrophin-associated protein A1 acidic component 1; acidic alpha 1 syntrophin; alpha-1-syntrophin; dJ1187J4.5; dystrophin-associated protein A1, 59kDa, acidic component; LQT12; pro-TGF-alpha cytoplasmic domain-interacting protein 1; SNT1; syntrophin-1; TACIP1

Goat

IgG

Alpha-1-syntrophin

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

-20°C or -80°C,2°C to 8°C

12352203