Synucleozid [502139-01-7]

MedChem Express

Synucleozid [502139-01-7]

10

502139-01-7

Research Use Only

C22H20N6

368.43

Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes alpha-synuclein protein. Synucleozid selectively targets the alpha-synuclein mRNA 5 UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinsons disease[1].

N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N

12352200