T-0156 [324572-93-2]

MedChem Express

T-0156 [324572-93-2]

10

324572-93-2

Research Use Only

C31H30ClN5O7

620.05

T-0156 is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 microM). T-0156 enhances the nitric oxide (NO)/cGMP pathway[1].

COC(C(N1CC2=CC=NC(C)=C2)=C(C3=CC(OC)=C(OC)C(OC)=C3)C4=CC=NC(OCC5=NC=CC=N5)=C4C1=O)=O.Cl

12352200