T-3861174 [2209057-94-1]

MedChem Express

T-3861174 [2209057-94-1]

5

2209057-94-1

Research Use Only

C26H25FN6O2

472.51

T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight[1].

O=C(C1=NC(C)=CC(N2C([C@@](C3CC3)(C#N)CC2)=O)=C1)NCC4=CC(C5=CN(C)N=C5)=CC(F)=C4

12352200