T-448 (free base)

MedChem Express

T-448 (free base) [1597426-52-2]

10

1597426-52-2

Research Use Only

C17H20N4OS

328.43

T-448 free base is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) , with an IC 50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons [1] .

O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2

12352200