T025 [2407433-00-3]
HY-112296
CAS Number2407433-00-3
Product group Chemicals
Estimated Purity98.01%
Molecular Weight382.42
Overview
- SupplierMedChem Express
- Product NameT025 [2407433-00-3]
- Delivery Days Customer10
- CAS Number2407433-00-3
- CertificationResearch Use Only
- Estimated Purity98.01%
- Molecular FormulaC21H18N8
- Molecular Weight382.42
- Scientific DescriptionT025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research.
- SMILESCNC1=NC(NCC2=NC=CC=N2)=C(C(C3=CC=C(N=CC=C4)C4=C3)=CN5)C5=N1
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200