T0901317

MedChem Express

T0901317 [293754-55-9]

10

293754-55-9

Research Use Only

99.93

C17H12F9NO3S

481.33

T0901317 is an orally active and highly selective LXR agonist with an EC 50 of 20 nM for LXRalpha [1] . T0901317 activates FXR with an EC 50 of 5 microM [2] . T0901317 is RORalpha and RORgamma dual inverse agonist with K i values of 132 nM and 51 nM, respectively [3] . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice [4] [5] .

OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1

-20°C,2°C to 8°C

12352200