T3Inh-1

Biorbyt

T3Inh-1 [50440-30-7]

10

50440-30-7

Research Use Only

C27H20N6O3

476.4861

T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 microM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream).

[N+](C1=CC=C2C(C(NC3C=CC(C(NC4C=CC(NC5C=CN=CC=5)=CC=4)=O)=CC=3)=CC=N2)=C1)([O-])=O

12352200