T6167923 [2437475-16-4]

TargetMol Chemicals

T6167923 [2437475-16-4]

4

2437475-16-4

Chemical

Research Use Only

T6167923

99.23%

C17H20BrN3O3S2

458.39

T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-kappaB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 microM for IFN-gamma, 2.9 microM for IL-1beta, and 2.66 microM each for IL-6 and TNF-alpha, demonstrating its efficacy across multiple inflammatory mediators [1].

3 years

C[C@H](NC(=O)N1CCN(CC1)S(=O)(=O)c1cccc(Br)c1)c1cccs1

-20°C

12352200