TAB2 Protein, Human, Recombinant (His & Myc)

TargetMol Chemicals

TAB2 Protein, Human, Recombinant (His & Myc)

16

Research Use Only

37.1 kDa (predicted)

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of Lys-63-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to Lys-63-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.

-20°C

12352200