Takeda-6D
HY-18318
Overview
- SupplierMedChem Express
- Product NameTakeda-6D [1125632-93-0]
- Delivery Days Customer10
- CAS Number1125632-93-0
- CertificationResearch Use Only
- Molecular FormulaC27H19ClFN5O3S
- Molecular Weight547.99
- Scientific DescriptionTakeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC 50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity [1] .
- SMILESO=C(NC1=CC(OC2=CC=C3C(SC(NC(C4CC4)=O)=N3)=N2)=CC=C1F)C5=CC=CC(C6(C#N)CC6)=C5Cl
- UNSPSC12352200