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ProductsBack/Takeda-6D [1125632-93-0]

Takeda-6D [1125632-93-0]

HY-18318

CAS Number1125632-93-0

Product group Chemicals

Molecular Weight547.99

Overview

Supplier
MedChem Express
Product Name
Takeda-6D [1125632-93-0]
Delivery Days Customer
10
CAS Number
1125632-93-0
Certification
Research Use Only
Molecular Formula
C27H19ClFN5O3S
Molecular Weight
547.99
Scientific Description
Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity[1].
SMILES
O=C(NC1=CC(OC2=CC=C3C(SC(NC(C4CC4)=O)=N3)=N2)=CC=C1F)C5=CC=CC(C6(C#N)CC6)=C5Cl
UNSPSC
12352200

MSDS

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