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Takeda-6D

HY-18318
MedChem Express
CAS Number1125632-93-0
Product group Chemicals
Molecular Weight547.99
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Takeda-6D [1125632-93-0]
  • Delivery Days Customer
    10
  • CAS Number
    1125632-93-0
  • Certification
    Research Use Only
  • Molecular Formula
    C27H19ClFN5O3S
  • Molecular Weight
    547.99
  • Scientific Description
    Takeda-6D (compound 6d) is an orally active and potent BRAF/VEGFR2 inhibitor, with IC 50 values of 7.0 and 2.2 nM, respectively. Takeda-6D shows antiangiogenesis by suppressing the VEGFR2 pathway in 293/KDR and VEGF-stimulated HUVEC cells.Takeda-6D shows significant suppression of ERK1/2 phosphorylation. Takeda-6D shows antitumor activity [1] .
  • SMILES
    O=C(NC1=CC(OC2=CC=C3C(SC(NC(C4CC4)=O)=N3)=N2)=CC=C1F)C5=CC=CC(C6(C#N)CC6)=C5Cl
  • UNSPSC
    12352200

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