Talmapimod (hydrochloride )

MedChem Express

Talmapimod (hydrochloride )

10

Research Use Only

C27H31Cl2FN4O3

549.46

Talmapimod (SCIO-469) hydrochloride is an orally active, selective, and ATP-competitive p38alpha inhibitor with an IC50 of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38beta, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs[1][2][3].

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)=O)C(Cl)=C2)=O.Cl

12352200