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ProductsBack/Tamnorzatinib (ONO-7475)

Tamnorzatinib (ONO-7475)

S8933

Estimated Purity...

Product group Chemicals

Overview

Supplier
Selleck Chemicals
Product Name
Tamnorzatinib (ONO-7475)
Delivery Days Customer
9
Certification
Research Use Only
Estimated Purity
...
Scientific Description
Tamnorzatinib (ONO-7475) is a potent, selective, and orally active novel inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 of 0.7 nM and 1.0 nM for AXL and MER, respectively. ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells. ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells.
UNSPSC
51202000

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