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ProductsBack/Tanshinone I [568-73-0]
Chemical Structure
Chemical Structure
Chemical Structure

Tanshinone I [568-73-0]

Research Use Only
CDX-T0417
Chemodex
CAS Number568-73-0
DownloadDatasheet
Product group Chemicals
Estimated Purity>98%
Molecular Weight276.29
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Overview

  • Supplier
    Chemodex
  • Product Name
    Tanshinone I [568-73-0]
  • Delivery Days Customer
    10
  • CAS Number
    568-73-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C18H12O3
  • Molecular Weight
    276.29
  • Scientific Description
    Chemical. CAS: 568-73-0. Formula: C18H12O3. MW: 276.29. Isolated from plant source. Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, anti-inflammatory, immunosuppressive, anticoagulant and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity. It has been shown to induce apoptosis in several cancer cell lines. It reduces plasma levels of total cholesterol, triglycerides, LDL and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in microglia in vitro. It is neuroprotective in a mouse model of Parkinsons disease induced by MPTP. - Tanshinone I is a diterpene that has been found in S. miltiorrhiza and has diverse biological activities, including anticancer, antidiabetic, anti-inflammatory, immunosuppressive, anticoagulant and neuroprotective properties. It inhibits proliferation in a variety of cancer cell lines, including KB/VCR, MCF-7/ADR, and K562/A02 multidrug resistance cell lines. It inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity. It has been shown to induce apoptosis in several cancer cell lines. It reduces plasma levels of total cholesterol, triglycerides, LDL and nonesterified fatty acids and decreases blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin and a high-fat diet. Tanshinone I reduces the LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in microglia in vitro. It is neuroprotective in a mouse model of Parkinsons disease induced by MPTP.
  • SMILES
    O=C(C1=C(C2=C3C(C)=CO2)C=CC4=C1C=CC=C4C)C3=O
  • Storage Instruction
    2°C to 8°C,RT
  • UNSPSC
    12352200