TAS-4 [794544-99-3]

MedChem Express

TAS-4 [794544-99-3]

9

794544-99-3

Research Use Only

C12H8Cl2N2O

267.11

TAS-4 is a potent and selective mGluR4 positive allosteric modulator with significant anti-Parkinsons disease activity. TAS-4 is able to show efficacy when used alone or in combination with l-DOPA. TAS-4 is able to reverse haloperidol-induced spasticity when administered alone. TAS-4 enhances the contralateral rotation behavior induced by l-DOPA in a dose-dependent manner. TAS-4 combined with low-dose l-DOPA shows anti-Parkinsons effects similar to full-dose l-DOPA without exacerbating abnormal motor side effects[1].

O=C(NC1=CC=C(C=C1Cl)Cl)C2=NC=CC=C2

12352200