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TC-E 5003

HY-107574
MedChem Express
CAS Number17328-16-4
Product group Chemicals
Estimated Purity98.03
Molecular Weight401.26
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Overview

  • Supplier
    MedChem Express
  • Product Name
    TC-E 5003 [17328-16-4]
  • Delivery Days Customer
    10
  • CAS Number
    17328-16-4
  • Certification
    Research Use Only
  • Estimated Purity
    98.03
  • Molecular Formula
    C16H14Cl2N2O4S
  • Molecular Weight
    401.26
  • Scientific Description
    TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 1.5 microM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-kappaB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers[1][2][3][4].
  • SMILES
    O=S(C1=CC=C(NC(CCl)=O)C=C1)(C2=CC=C(NC(CCl)=O)C=C2)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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