TC-N 1752 [1211866-85-1]

MedChem Express

TC-N 1752 [1211866-85-1]

10

1211866-85-1

Research Use Only

99.67

C25H27F3N6O3

516.52

TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 microM, 0.3 microM, 0.4 microM, 1.1 microM and 2.2 microM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain[1][2][3].

FC(F)(F)OC(C=C1)=CC=C1COC(CC2)CCN2C3=NC=NC(NC4=C(C(NC(C)=O)=CC=C4)C)=N3

-20°C,2°C to 8°C

12352200