TC14012 [368874-34-4]

MedChem Express

TC14012 [368874-34-4]

10

368874-34-4

Research Use Only

99.90

C90H140N34O19S2

2066.42

TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting beta-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity[1][2].

O=C1[C@@]2([H])N(CCC2)C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](N1)CC3=CC=C(C=C3)O)=O)CCCNC(N)=N)=O)CCCNC(N)=O)=O)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)CC4=CC5=C(C=CC=C5)C=C4)=O)=O)CC6=CC=C(C=C6)O)=O)CCCNC(N)=O)=O)CCCCN)=O)CCCNC(N)=O)=O

-20°C,-80°C

12352202