TD-428 [2334525-50-5]
HY-114407
CAS Number2334525-50-5
Product group Chemicals
Estimated Purity98.81
Molecular Weight879.38
Overview
- SupplierMedChem Express
- Product NameTD-428 [2334525-50-5]
- Delivery Days Customer10
- CAS Number2334525-50-5
- CertificationResearch Use Only
- Estimated Purity98.81
- Molecular FormulaC43H43ClN10O7S
- Molecular Weight879.38
- Scientific DescriptionTD-428 is a PROTAC connected by ligands for Cereblon and BRD4. TD-428 is a highly specific BRD4 degrader with a DC50 of 0.32 nM[1]. TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation[1].
- SMILESO=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
