TDI-015051

MedChem Express

TDI-015051

5

Research Use Only

C22H22FN5O4S

471.50

TDI-015051 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 (NSP14) with an IC50 ≤0.15 nM. TDI-015051 inhibits SARS-CoV-2 NSP14 in Huh-7.5 cell (EC50=11.4 nM) and in ACE2-TMPRSS2 expressing A549 cell (EC50=64.7 nM). TDI-015051 also inhibits other coronaviruses like alpha-hCoV-NL63, alpha-hCoV-229E and beta-hCoV-MERS with IC50s of 1.7, 2.6 and 3.6 nM, respectively. TDI-015051 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and viral replication, and exhibits anti-infectious activity in mouse models[1].

O=S(N(CC1)CC2=C1NN=C2)(C3=C(C)N(C)C(C(NCC4=C(F)C=CC5=C4C=CO5)=O)=C3)=O

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