TDRL-551 [1644626-43-6]

MedChem Express

TDRL-551 [1644626-43-6]

10

1644626-43-6

Research Use Only

99.84

C25H23ClIN3O4

591.83

TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 microM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].

O=C(CCCC(N1N=C(CC1C2=CC3=CC=C(C=C3N=C2Cl)OCC)C4=CC=C(C=C4)I)=O)O

-20°C,2°C to 8°C

12352200