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TED-347 [2378626-29-8]

HY-125269
MedChem Express
CAS Number2378626-29-8
Product group Chemicals
Estimated Purity98.97
Molecular Weight313.70
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Overview

  • Supplier
    MedChem Express
  • Product Name
    TED-347 [2378626-29-8]
  • Delivery Days Customer
    5
  • CAS Number
    2378626-29-8
  • Certification
    Research Use Only
  • Estimated Purity
    98.97
  • Hazard Information
    h302, h314
  • Molecular Formula
    C15H11ClF3NO
  • Molecular Weight
    313.70
  • Scientific Description
    TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 microM for TEAD4 Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 microM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
  • SMILES
    O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

MSDS

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