Tefinostat(CHR-2845)

Selleck Chemicals

Tefinostat(CHR-2845) [914382-60-8]

9

Research Use Only

...

Tefinostat(CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase (HDAC). Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.

51202000