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Telaglenastat

HY-12248
MedChem Express
CAS Number1439399-58-2
DownloadMSDS
Product group Chemicals
Estimated Purity99.92
Molecular Weight571.57
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Telaglenastat [1439399-58-2]
  • Delivery Days Customer
    10
  • CAS Number
    1439399-58-2
  • Certification
    Research Use Only
  • Estimated Purity
    99.92
  • Molecular Formula
    C26H24F3N7O3S
  • Molecular Weight
    571.57
  • Scientific Description
    Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity[1].
  • SMILES
    O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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