TEM4 antibody

GeneTex

TEM4 antibody

9

WB: 0.5 - 1 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ARHGEF17

Rho guanine nucleotide exchange factor 17

P164RHOGEF, RHOGEF17, TEM4, p164-RhoGEF, rho guanine nucleotide exchange factor 17, 164 kDa Rho-specific guanine-nucleotide exchange factor, Rho guanine nucleotide exchange factor (GEF) 17, Rho-specific guanine-nucleotide exchange factor 164 kDa, tumor endothelial marker 4

Rabbit

IgG

Rho guanine nucleotide exchange factor 17

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.

-20°C or -80°C,2°C to 8°C

12352203